A new study led by Vanderbilt-Ingram Cancers Center researcher David Gius.

But how deficiency in a longevity gene resulted in increased ROS was not very clear. Since superoxide is generally taken off the cell by using a detoxifying enzyme known as manganese superoxide dismutase , Gius hypothesized that the Sirt3 deficiency might regulate MnSOD abnormally. In today’s study, the researchers display that Sirt3 knockout mice have decreased MnSOD activity despite having normal levels of the protein. Gius and colleagues established that the MnSOD in Sirt3 knockout mice was abnormally altered at a specific amino acid . This aberrant modification of MnSOD decreased the enzyme’s capability to detoxify superoxide and seemed to explain the increase in ROS in Sirt3 knockout mouse tumors. These results suggest that aberrant regulation of MnSOD is important in receptor positive breast cancer, said Gius.In the largest study of its kind, experts at the University of Missouri identified that many college students drink to surplus on the 21st birthdays and potentially jeopardize their wellness. The study will appear in the June issue of the Journal of Consulting and Clinical Psychology, which is released by the American Psychological Association. The data were collected from a larger study where college students at one university were implemented for four years and asked queries about their drinking behaviors. The participants had already turned 21 and had been asked whether they had drunk alcohol to celebrate turning 21, and, if so, how much they had drunk and for how lengthy.