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Margins benefited from recent acquisitions and the impact of the cost reduction initiatives and facility optimization activities, offset by product mix within the Active Pharmaceutical Substances segment. Adjusted agreement margins exclude purchase accounting amortization and depreciation, as well as share-based compensation expenditure that are included under U.S. GAAP. For a reconciliation of U.S. GAAP contract margins as reported to modified agreement margins for the 2015 and 2014 reporting periods, please see Table 1 at the final end of press release.The Virginia G. Piper Cancers Center at Scottsdale Health care was the first ever to offer patient usage of ASG-5ME. Researchers hope to enroll up to 50 patients in scientific trials of the medication in multiple centers over the U.S. The drug was co-created by Seattle Genetics, Inc. Of Bothell, Clean. And Agensys, Inc., an affiliate of Tokyo-centered Astellas Pharma Inc. More than 36,000 folks are expected to die from pancreatic cancers in 2010 2010, based on the American Cancer Society.